Melanostatin DM is a synthetic oligopeptide supplied exclusively for laboratory research applications. The compound is investigated in preclinical and in vitro experimental systems for its ability to modulate melanocortin signaling pathways, specifically through antagonism of α-melanocyte-stimulating hormone (α-MSH). These studies focus on regulation of melanin biosynthesis at the cellular and enzymatic level without implication of applied or physiological outcomes.

Sequence: (Three-Letter Code): His-D-Arg-Ala-Trp-D-Phe-Lys
Molecular formula: C41H58N14O6
Molecular weight: 842 g/mol

Melanostatin DM is an extended peptide analog of melanostatin, incorporating D-amino acid substitutions to enhance stability in experimental environments. The sequence design confers selective interaction with α-MSH–related signaling while minimizing off-target activity observed in shorter endogenous melanostatin fragments. Structural studies describe its role as a competitive antagonist within melanocortin-associated pathways.

Melanostatin DM is utilized in laboratory research to investigate regulation of melanocyte signaling and melanin synthesis. Experimental applications include in vitro melanocyte cultures and animal models to evaluate modulation of α-MSH–mediated pathways and downstream enzymatic processes associated with melanin production.

Melanostatin DM functions as an antagonist of α-melanocyte-stimulating hormone signaling. By inhibiting α-MSH interaction with melanocortin receptors, the peptide reduces activation of downstream signaling cascades that regulate tyrosinase expression and activity. Tyrosinase is a key rate-limiting enzyme in melanin biosynthesis, and modulation of this pathway is studied to characterize control points within pigment-related biochemical networks.

Preclinical investigations involving Melanostatin DM include animal models and cultured melanocyte systems assessing changes in melanin synthesis following α-MSH pathway inhibition. Experimental observations report reduced melanin production metrics relative to control conditions. These findings are used to examine melanocortin pathway regulation and peptide structure–function relationships under controlled research conditions.

Melanostatin DM is supplied as a synthetic research-grade peptide. Identity and purity are typically confirmed using analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS). Storage and handling should follow standard laboratory protocols appropriate for peptide-based research reagents.

1. Abu Ubeid, A., Zhao, L., Wang, Y. & Hantash, B. M. Short-sequence oligopeptides with inhibitory activity against mushroom and human tyrosinase. J. Invest. Dermatol. 129, 2242–2249 (2009).
2. Thorsen, M., Yde, B., Pedersen, U., Clauden, K. & Lawesson, S.-O. Studies on amino acids and peptides-V. Tetrahedron 39, 3429–3435 (1983).
3. MELANOSTATINE® 5 by Lucas Meyer Cosmetics – Personal Care & Cosmetics. Available at: https://www.ulprospector.com/en/na/PersonalCare/Detail/4501/124875/MELANOSTATINE-5. (Accessed: 28th July 2016)

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

For Laboratory Research Only. Not for human use, medical use, diagnostic use, or veterinary use.