BPC-157 is a synthetic pentadecapeptide derived from a larger endogenous gastric protein complex known as Body Protection Compound (BPC). The peptide consists of a defined 15–amino acid sequence and has been examined in preclinical experimental systems for molecular stability and biochemical activity.

Within laboratory research environments, BPC-157 is used as a molecular probe to investigate cellular migration, extracellular matrix dynamics, angiogenic signaling pathways, oxidative stress modulation, and cytoskeletal organization. All data associated with this peptide are derived exclusively from in-vitro and in-vivo animal research models.

Source: PubChem

Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Molecular Formula: C62H98N16O22
Molecular Weight: 1419.556 g/mol
PubChem CID: 108101

BPC-157 is a linear peptide lacking disulfide bonds. Its proline-rich sequence contributes to conformational rigidity and reduced susceptibility to proteolytic degradation, supporting stability in aqueous experimental systems.

BPC-157 is supplied exclusively for laboratory research use and has been employed in controlled experimental studies examining:

• Fibroblast proliferation and directional migration
• Endothelial cell growth and angiogenic pattern formation
• Extracellular matrix deposition and remodeling
• Cytoskeletal organization and focal adhesion signaling
• Oxidative stress marker modulation in animal models
• Nitric oxide–associated biochemical pathways

All applications are limited to non-clinical research systems designed to elucidate fundamental biological mechanisms.

Mechanistic investigations indicate that BPC-157 modulates signaling pathways involved in cellular motility and vascular organization. Experimental data suggest interaction with VEGFR2-associated signaling cascades and downstream nitric oxide–related molecular processes.

Additional in-vitro findings describe phosphorylation changes in focal adhesion signaling proteins involved in cytoskeletal anchoring and cell migration. These observations support use as a probe for cytoskeletal remodeling pathways in controlled experimental systems.

Published preclinical literature documents investigations of BPC-157 across multiple experimental models. In rodent systems, the peptide has been studied in research examining vascular recruitment, gastrointestinal tissue integrity, and connective tissue remodeling under controlled laboratory conditions.

Additional investigations in avian and invertebrate models have explored peptide stability and tissue-level stress responses, contributing to broader understanding of conserved biological signaling mechanisms.

BPC-157 concentration versus vascular endothelial cell growth
Source: PubMed

BPC-157 is supplied as a lyophilized peptide produced via solid-phase peptide synthesis. Each lot undergoes analytical verification using high-performance liquid chromatography and mass spectrometry to confirm molecular identity and purity.

Analytical data are provided to support reproducibility and consistency in laboratory workflows.

1. T. Huang et al., “Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro,” Drug Des. Devel. Ther., vol. 9, pp. 2485–2499, 2015.
2. D. Drmic et al., “Counteraction of perforated cecum lesions in rats: Effects of pentadecapeptide BPC 157, L-NAME and L-arginine,” World J. Gastroenterol., vol. 24, no. 48, pp. 5462–5476, Dec. 2018.
3. F. Amic et al., “Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine,” World J. Gastroenterol., vol. 24, no. 47, pp. 5366–5378, Dec. 2018.
4. A. Duzel et al., “Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights,” World J. Gastroenterol., vol. 23, no. 48, pp. 8465–8488, Dec. 2017.
5. J. Vukojević et al., “Rat inferior caval vein (ICV) ligature and particular new insights with the stable gastric pentadecapeptide BPC 157,” Vascul. Pharmacol., vol. 106, pp. 54–66, 2018.
6. D. Drmic et al., “Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME,” World J. Gastroenterol., vol. 23, no. 29, pp. 5304–5312, Aug. 2017.
7. M.-J. Hsieh et al., “Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation,” J. Mol. Med. Berl. Ger., vol. 95, no. 3, pp. 323–333, 2017.
8. Z. Grabarevic et al., “The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks,” J. Physiol. Paris, vol. 91, no. 3–5, pp. 139–149, Oct. 1997.
9. P. Sikiric et al., “Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157. Vascular Recruitment and Gastrointestinal Tract Healing,” Curr. Pharm. Des., vol. 24, no. 18, pp. 1990–2001, 2018.
10. S. Seiwerth et al., “BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing,” Curr. Pharm. Des., vol. 24, no. 18, pp. 1972–1989, 2018.
11. C.-H. Chang et al., “The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration,” J. Appl. Physiol., vol. 110, no. 3, pp. 774–780, Oct. 2010.
12. Y.-L. Hu et al., “FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells,” Sci. Rep., vol. 4, p. 6024, Aug. 2014.
13. K. Škrlec et al., “Engineering recombinant Lactococcus lactis as a delivery vehicle for BPC-157 peptide with antioxidant activities,” Appl. Microbiol. Biotechnol., vol. 102, no. 23, pp. 10103–10117, Dec. 2018.
14. D. Strinic et al., “BPC 157 counteracts QTc prolongation induced by haloperidol, fluphenazine, clozapine, olanzapine, quetiapine, sulpiride, and metoclopramide in rats,” Life Sci., vol. 186, pp. 66–79, Oct. 2017.
15. N. Jelovac et al., “Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats,” Eur. J. Pharmacol., vol. 379, no. 1, pp. 19–31, Aug. 1999.
16. I. Tlak Gajger et al., “Stable gastric pentadecapeptide BPC 157 in honeybee (Apis mellifera) therapy, to control Nosema ceranae invasions in apiary conditions,” J. Vet. Pharmacol. Ther., vol. 41, no. 4, pp. 614–621, Aug. 2018.

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

For Laboratory Research Only. Not for human use, medical use, diagnostic use, or veterinary use.