Nonapeptide-1, also referred to as Melanostatine™ 5, is a synthetic nonapeptide supplied exclusively for laboratory research applications. The peptide was initially characterized in microbial systems and is investigated in preclinical and in vitro models for its role in modulation of melanogenesis-related biochemical pathways. Research focuses on peptide-mediated regulation of pigment-associated enzymatic activity at the cellular level.

Sequence (Three-Letter Code): Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val
Molecular formula: C61H87N15O9S
Molecular weight: 1206.52 g/mol

Nonapeptide-1 is a sulfur-containing oligopeptide incorporating both L- and D-amino acid residues, contributing to enhanced stability in experimental environments. The sequence architecture enables interaction with enzymatic systems involved in melanin biosynthesis, particularly through modulation of tyrosinase-associated activity observed in fungal, cellular, and animal research models.

Nonapeptide-1 is utilized in laboratory research to investigate regulation of melanin synthesis and pigment-related cellular signaling. Experimental applications include fungal systems, cultured melanocyte models, and in vivo animal studies to evaluate peptide effects on tyrosinase activity and melanin content under controlled conditions.

Additional preclinical investigations explore Nonapeptide-1 interactions with neurochemical signaling pathways in animal models, including receptor systems associated with dopaminergic and opioid signaling, to characterize broader peptide–receptor structure–function relationships.

Nonapeptide-1 is studied for its ability to inhibit melanogenesis through interference with tyrosinase activity, a rate-limiting enzyme in melanin biosynthesis. Preclinical data also suggest modulation of melanocyte-stimulating hormone (MSH)–related signaling pathways, which regulate transcriptional and enzymatic processes associated with pigment production. These mechanisms are examined exclusively in experimental research systems.

Preclinical research involving Nonapeptide-1 includes fungal assays, cultured melanocyte experiments, and animal models evaluating changes in melanin synthesis following peptide exposure. Experimental observations report measurable reductions in tyrosinase activity and melanin production relative to controls. These findings are used to characterize pigment-regulatory biochemical pathways and peptide structure–activity relationships without implication of applied outcomes.

Nonapeptide-1 is supplied as a synthetic research-grade peptide. Identity and purity are typically confirmed using analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS). Storage and handling should follow standard laboratory protocols applicable to peptide-based research reagents.

1. R, B., R, S., B, S., B, M. & J, P. Central action of melanostatin (MIF-1) in mice. Acta Physiol. Pol. 35, 447–453 (1983).
2. Ishihara, Y. et al. Melanostatin, a new melanin synthesis inhibitor. Production, isolation, chemical properties, structure and biological activity. J. Antibiot. (Tokyo) 44, 25–32 (1991).
3. MelanostatineTM 5 – Lucas Meyer Cosmetics – datasheet. Available at: http://cosmetics.specialchem.com/product/i-lucas-meyer-cosmetics-melanostatine-5. (Accessed: 28th July 2016)
4. Abu Ubeid, A., Zhao, L., Wang, Y. & Hantash, B. M. Short-sequence oligopeptides with inhibitory activity against mushroom and human tyrosinase. J. Invest. Dermatol. 129, 2242–2249 (2009).
5. MELANOSTATINE® 5 by Lucas Meyer Cosmetics – Personal Care & Cosmetics. Available at: https://www.ulprospector.com/en/na/PersonalCare/Detail/4501/124875/MELANOSTATINE-5. (Accessed: 28th July 2016)

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

For Laboratory Research Only. Not for human use, medical use, diagnostic use, or veterinary use.